But, umm, is it going to hurt me if I don't think I'm familiar with the story this is crossed with (considering that I haven't figured it out yet, I either don't know it or I'm really slow. Actually, either is possible. Hmm.)?

It's my hope that not knowing Alias won't be a disadvantage when you read this. I want the story to be enhanced if you know the x-over, but not a requirement.